Setria® Glutathione: What It Is, How It Works, and Why Your Body Might Thank You
What Is Glutathione?
Glutathione is a tripeptide composed of three amino acids—glutamine, cysteine, and glycine. It’s produced naturally by your body and found in every single cell, where it acts as a powerful antioxidant.
Its primary roles include:
- Neutralizing harmful free radicals
- Recycling other antioxidants (like vitamins C and E)
- Supporting immune function
- Detoxifying the liver
- Protecting mitochondria and DNA
Basically, if your cells had a security team, glutathione would be the head of it.
Why Your Glutathione Levels Decline
As you age—or subject your body to things like stress, poor diet, toxins, alcohol, and intense exercise—your glutathione levels drop.
Low glutathione has been linked to:
- Weakened immune function
- Slower recovery after exercise
- Increased inflammation and oxidative stress
- Fatigue and cellular damage
Not All Glutathione Supplements Work
Early research suggested that oral glutathione wasn’t very effective because it would be broken down in the digestive tract before being absorbed. This led to a wave of liposomal glutathione products and other delivery methods.
But that’s where Setria® Glutathione changes the game.
What Makes Setria® Glutathione Different?
Setria® is a patented, clinically studied form of reduced glutathione developed by Kyowa Hakko. It’s manufactured through a unique fermentation process to ensure purity, stability, and bioavailability.
Unlike generic glutathione, Setria® has been proven in human trials to raise blood glutathione levels and improve antioxidant status. Let's take a look at the science.
Clinical Research on Setria® Glutathione
1. Oral Supplementation Study (2015)
A double-blind, placebo-controlled study published in the European Journal of Nutrition gave participants either 250 mg or 1,000 mg of Setria® daily for six months.
Results:
- 30–35% increase in whole blood glutathione levels
- Improved lymphocyte and erythrocyte glutathione status
- Decreased oxidative stress markers
- Enhanced natural killer (NK) cell function
2. Exercise Recovery and Blood Flow Study
Another study combining glutathione with L-citrulline found improved nitric oxide production, reduced oxidative stress, and better performance in resistance-trained men.
This suggests a potential role for Setria® in supporting athletic recovery and performance.
How Setria® Glutathione Works in the Body
Once ingested, Setria® (in its reduced form) is absorbed through the small intestine and enters the bloodstream. From there, it helps:
- Neutralize free radicals
- Regenerate other antioxidants like vitamin C
- Support detoxification through the liver
- Reduce systemic inflammation and oxidative stress
Top Benefits of Setria® Glutathione
1. Potent Antioxidant Defense
Glutathione helps protect cells from damage caused by free radicals and supports overall oxidative balance.
2. Immune System Support
Setria® has been shown to enhance NK cell activity, making it a critical tool for keeping your immune system on point.
3. Liver Detoxification
Glutathione plays a key role in phase II liver detoxification and helps escort toxins and heavy metals out of the body.
4. Exercise Recovery
By reducing oxidative stress, Setria® may reduce muscle fatigue and speed up recovery after hard training sessions.
5. Skin Health and Radiance
Some studies suggest oral glutathione can help brighten skin and reduce melanin production. Setria® is often used in beauty supplements for this reason.
6. Brain Health and Longevity
Glutathione protects neurons and has been linked to brain longevity. Low GSH is associated with cognitive decline and neurodegeneration.
How to Use Setria® Glutathione
Recommended dose: 250 mg to 1,000 mg per day, preferably on an empty stomach.
Stack it with:
- Vitamin C or Alpha-lipoic acid for recycling glutathione
- L-Citrulline or beetroot for blood flow and performance
- NAC (N-acetyl cysteine) to support natural GSH production
Is It Safe?
Yes. Setria® is GRAS (Generally Recognized As Safe) and has shown excellent tolerability in clinical studies. It’s bioidentical to the glutathione your body already produces.
The Bottom Line
Glutathione is one of the most underrated nutrients for health, recovery, detoxification, and immune support. And Setria® Glutathione? It’s the most studied, reliable, and bioavailable oral glutathione on the market.
If you’re looking to upgrade your supplement stack with something that supports your health from the inside out, Setria® is worth the spot.
References
- Pizzorno J. Glutathione! Integr Med (Encinitas). 2014;13(1):8–12.
- Wu G, et al. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489–492.
- Witschi A, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol. 1992;43(6):667–669.
- Richie JP Jr, et al. Randomized controlled trial of oral glutathione supplementation. Eur J Nutr. 2015;54(2):251–263.
- Bailey SJ, et al. L-citrulline and glutathione supplementation. J Int Soc Sports Nutr. 2015;12:27.
- Lu SC. Regulation of glutathione synthesis. Mol Aspects Med. 2009;30(1–2):42–59.
- Arjinpathana N, Asawanonda P. Glutathione as an oral whitening agent. J Dermatolog Treat. 2012;23(2):97–102.
- Sian J, et al. Alterations in glutathione levels in neurodegenerative disorders. Lancet. 1994;344(8928):796–798.
